Ilex vomitoria, commonly known as yaupon () or yaupon holly, is a species of holly that is native to southeastern North America. The word yaupon was derived from the Catawban yą́pą, from yą- tree + pą leaf. Another common name, cassina, was borrowed from Timucua (despite this, it usually refers to Ilex cassine). The Latin name comes from an observation by early Europeans that the ingestion of the plant was followed by vomiting in certain ceremonies.

The plant was traditionally used by Native Americans to make an infusion containing caffeine. It is only one of two known plants endemic to North America that produce caffeine. The other (containing 80% less) is Ilex cassine, commonly known as dahoon holly. Yaupon is also widely used for landscaping in its native range.